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Cannes Review: Lee Jung-Jae’s ‘Hunt’

May 19, 2022 by deadline.com Leave a Comment

Although a star for nearly 30 years in South Korean films, Lee Jung-Jae recently rocketed to international fame on a whole other level as the star of the television phenomenon, The Squid Game . All of that spotlight will add to interest in Hunt, which he not only stars, produces, co-wrote (with Jo Seung-Hee), but makes his feature film directorial debut, one that just had its World Premiere in the Midnight section of the Cannes Film Festival.

Taking on all these extra jobs can be perilous for an actor on his level but it is easy to see why Hunt, an action-filled, character-driven psychological espionage tale was appealing for the star. First it offers a crackerjack role as Park Pyong-Ho, leader of the Korean  Central Intelligence Agency’s Foreign Unit, plus a constantly twisting plotline that lends itself not only to several well-executed action set pieces and global intrigue, but also has some pertinent things to say about the danger of misinformation and dictatorships even as it is set in the 1980’s.  On top on that it has a classic match up in which two veteran stars get to face off against each other, the second being a terrific  Jung Woo-Song as KCIA’s Domestic Unit head Kim Jung-Do assigned to take on an investigation that pits him directly against Pyong-Ho. Both actors are up to the task in this riveting fast moving commercial thriller that, like Squid Game, is in a friendly genre that ought to travel well internationally, as well as in its home country.

The basic set up reveals the existence of a mole known as Donglim in the KCIA, their dangerous leaks causing mayhem for Pyong-Ho who was helping a high profile defector seek asylum until it blew up. Essentially the agency pits the domestic and foreign units against each other in a race to plug the leaks and uncover the identity of the mole. Unfortunately Pyong-Ho becomes suspect number one  for Jung-Do, ratcheting up the tension and suspicions between the long time colleagues, and on top of everything else leading to information about a planned assasination attempt of the dictatorial leader of South Korea in a time where the truth was obscured and molded into misinformation and distrust between the two Koreas. Although different from the situation today, Hunt finds some interesting parallels in the dangers of what is now dubbed fake news. It becomes psychological warfare between the pair, with Jung-Do interviewing every associate of Pyong-Ho in an attempt to uncover the real truth, a slippery slope that leads to violence and, fortunately for viewers a lot of edge-of-your-seat action to keep this all from becoming so political your eyes glaze over. Both stars are excellent with three dimensional roles that offer some nifty turns in the story leading to a climax where Director Lee manages to squeeze out every ounce of suspense and importantly, humanity and emotion.

A supporting cast with richly defined roles is also key to making Hunt work. Jeon Hye-Jin as sprightly Agent  Ju-Kyung is a great addition as the right hand to Pyong-Ho and she makes the most of her screen time, as does the young woman You-Jung who in a few scenes proves key and is well-played by Go Youn Jung.  Heo Sung-Tae also fills the bill nicely as Kim’s henchman of sorts, Agent Cheol-Sung. The technical contributions are aces, particularly cinematographer Lee Mo Gae who finds inventive camera angles to make what might have seemed familiar in the genre quite fresh and inventive in its style.

This is the kind of movie plot about the less said the better, but fortunately the focus is on the characters pitted against each other, rather than the countries themselves and that is crucial to making this time bomb of a movie keep ticking as well as it does over the course of two+ hours.

Megabox Plus M, Artist Studio, and Sinai Pictures are the production entities for the film which is up for sale in Cannes.

Filed Under: Awardsline "Hunt", Cannes, Cannes Film Festival, Lee Jung-jae, Squid Game

Senate Passes $40 Billion in Aid to Ukraine During 40-Year-High Inflation

May 19, 2022 by www.breitbart.com Leave a Comment

The Senate on Thursday passed legislation to give $40 billion to Ukraine in economic and military aid, while Americans suffer from food shortages and inflation.

The Senate voted on H.R. 7691, the Ukraine Supplemental Aid Package, which passed 86-11. The vote featured strong Republican and Democrat support for the bill; however, some populist Senate Republicans opposed the legislation, believing that America should focus its efforts on domestic crises such as 40-year-high inflation and baby formula shortages.

Sens. Marsha Blackburn (R-TN), John Boozman (R-AR), Mike Crapo (R-ID), Bill Hagerty (R-TN), Josh Hawley (R-MO), Mike Lee (R-UT), Roger Marshall (R-KS), Cynthia Lummis (R-WY), Rand Paul (R-KY), Mike Braun (R-IN), and Tommy Tuberville (R-AL) voted against the bill.

Senate Republican populists could not stop the overwhelming Senate support to stop the legislation, even though it required 60 votes, but Sen. Rand Paul (R-KY) managed to delay the passage of the bill until Thursday.

Paul told Breitbart News Daily host Alex Marlow that the United States would have to borrow the $40 billion to send the tens of billions of dollars in aid to Ukraine. The Senate did not vote on Paul’s proposed amendment to have an inspector general ensure the billions were spent wisely.

Paul lamented the “bipartisan consensus” that Republicans need to give Democrats more social welfare spending to obtain more military spending.

The bill’s delay garnered extra attention for the legislation, which led many lawmakers to question the need to increasingly have the United States intervene on behalf of Ukraine during its conflict with Russia.

Sen. Josh Hawley (R-MO) also became a sharp detractor of the Ukraine aid bill, contending that it is not in America’s interests.

“Spending $40 billion on Ukraine aid – more than three times what all of Europe has spent combined – is not in America’s interests. It neglects priorities at home (the border), allows Europe to freeload, short changes critical interests abroad and comes w/ no meaningful oversight,” Hawley wrote.

“That’s not isolationism. That’s nationalism. It’s about prioritizing American security and American interests,” he added.

Spending $40 billion on Ukraine aid – more than three times what all of Europe has spent combined – is not in America’s interests. It neglects priorities at home (the border), allows Europe to freeload, short changes critical interests abroad and comes w/ no meaningful oversight

— Josh Hawley (@HawleyMO) May 16, 2022

Hawley said , “The $40 billion Ukraine bill represents a return to nation building. Wrong choice. I’m a no.”

“I support helping Ukraine expel the Russian invasion, but as inflation, gas prices, and shortages wallop Americans here at home I can’t support $40 billion of new spending unless it’s offset with cuts or taken from already authorized funds, especially when the European Union isn’t matching what we’re doing to end this conflict in their own backyard,” Braun, who voted against the legislation, said in a statement this week.

“I am fully in support of Ukraine and its efforts to push back on Russian aggression. I am, however, concerned about this particular request. President Biden requested $33 billion, yet we are voting on a $40 billion package. It’s important to give Ukraine the support they need, but we also need to be pragmatic about the amount of money we are spending,” Lummis, who also voted against the bill, said in a statement.

In contrast, Sen. Mitt Romney (R-UT), contended that America needs to send Ukraine the tens of billions of dollars in aid to “stand with the freedom-loving people of Ukraine.”

Ukrainians are fighting for their freedom while being brutally violated by Russia. I will be voting for the Ukraine bill because it is in America’s interest to do so. And it is also simply the right thing to do. I am proud to stand with the freedom-loving people of Ukraine. pic.twitter.com/iV1SlY7c81

— Senator Mitt Romney (@SenatorRomney) May 19, 2022

Sen. Lindsey Graham (R-SC) said, “America is by nature a noninterventionist nation. However, America has historically been the arsenal of democracy and stood up for freedom when very few would.”

America is by nature a noninterventionist nation. However, America has historically been the arsenal of democracy and stood up for freedom when very few would. https://t.co/CpZe4wMEEH

— Lindsey Graham (@LindseyGrahamSC) May 19, 2022

Sen. Jim Inhofe (R-OK)) said, “Let’s be clear: Supporting Ukraine in its war against Russia puts U.S. security interests first. We also need to be clear that for the last 17 months, @ POTUS could have done much more to deter Russia & much less to appease Putin.”

Let’s be clear: Supporting Ukraine in its war against Russia puts U.S. security interests first. We also need to be clear that for the last 17 months, @POTUS could have done much more to deter Russia & much less to appease Putin.

My op-ed in @TheHill ↓ https://t.co/aim07yuYRy

— Sen. Jim Inhofe (@JimInhofe) May 19, 2022

The Ukraine aid package also passed through the House with overwhelming Democrat and Republican support, although 57 Republicans voted against the legislation.

Breitbart News defense reporter Kristina Wong broke down the spending for the Ukraine aid package, which includes $20 billion for the Department of Defense:

— $17 billion for U.S. military operations, including the Ukraine Security Assistance Initiative, and to replace U.S. military equipment sent to Ukraine;

Roughly $20 billion was for Ukraine, the State Department, international organizations, and other agencies, including:

— $8.77 billion in economic assistance for Ukraine;

The legislation goes to President Joe Biden’s desk to sign.

Sean Moran is a congressional reporter for Breitbart News. Follow him on Twitter @SeanMoran3 .

Filed Under: Uncategorized Joe Biden, Josh Hawley, military aid, Rand Paul, Senate, Ukraine, Politics, hiv aids deaths per year, probiotic 40 billion, sky high inflatables, 40 billion, senate passes health care bill, senate passes tax reform bill, yearly us inflation rates, aids deaths by year, yearly us inflation rate, senate passed bill today

For Carol Burnett, the Sondheim award is personal

May 19, 2022 by www.chron.com Leave a Comment

When Stephen Sondheim asked his friend Carol Burnett years ago if she would come to New York and sing “I’m Still Here” from “Follies,” she instantly agreed. Though somehow, Burnett had failed to absorb one crucial detail: She would be required to belt the number for, gulp, an audience of 2,700 Sondheim freaks in Lincoln Center’s Avery Fisher Hall.

“He said ‘a recording,’ ” Burnett recalled, laughing. “I’m thinking we’re gonna be in a booth, and I’m gonna have a microphone and the lyrics in front of me. I flew back to New York, and I’m having lunch with my darling Beverly Sills. And she said, ‘Well, we’re going to see you when you do “Follies.” ‘ I said, ‘Oh, you’re going to be in the booth?’ ”

That 1985 concert – with the likes of Barbara Cook, Mandy Patinkin, Elaine Stritch, George Hearn and Lee Remick – is a milestone in the Sondheim annals. Burnett could still chuckle at the memory of her misapprehension as she reminisced last Sunday in an elegant meeting room at the Ritz-Carlton in Tysons in Northern Virginia. The next day, Signature Theatre would bestow on her its Stephen Sondheim Award, whose past recipients have included Angela Lansbury, Harold Prince, Bernadette Peters, Patti LuPone and Audra McDonald.

The pandemic delayed the honoring of Burnett for two years, and then in November the revered Broadway composer died, at 91. One poignant result is that Burnett – who met Sondheim six decades ago, when both had just begun to make their marks – is the last person handpicked by Sondheim to receive the award.

Reminded of that fact, Burnett grew misty. Behind tinted glasses, she teared up. “I know, and it just breaks my heart,” she said of the turn of events. “I’m thrilled about this award, because he picked me.”

At 89, Burnett – a Broadway baby to her core but more lovingly remembered for “The Carol Burnett Show,” the hour-long variety show she headlined on CBS for 279 episodes from 1967 to 1978 – remains as sharp and engaging as ever. For the tribute to her that Signature orchestrated Monday night at the Capital One Hall in Tysons, the performers included Peters, the first person she ever asked to appear on the TV show, after seeing her in an off-Broadway musical, “Dames at Sea.”

“When no one else would have me, you hired me,” Peters recounted from the stage, after serenading Burnett with “Old Friends” from Sondheim and George Furth’s “Merrily We Roll Along.”

Friends of more recent vintage showed up, too: Tony-winning actor Santino Fontana, for whom Burnett flew in from California for his opening night in the stage version of “Tootsie,” and political satirist and social media sensation Randy Rainbow, with whom Burnett became email chums during the pandemic – and finally met him (and his mother, Gwen Rainbow) in person Monday night.

“We bonded,” Randy Rainbow told the crowd, “over our shared love of Sondheim and cats – the animal, not the musical.”

Burnett has an impressive trophy case filled with Emmys and Golden Globes and Kennedy Center Honors, but a Sondheim Award justifiably pegs her as in that inner circle of performers and directors and musicians whom the composer cherished. She famously emerged as a musical theater star in 1959, playing Princess Winnifred in “Once Upon a Mattress,” a spoof of “The Princess and the Pea” fairy tale, with music by Mary Rodgers, daughter of Richard. Her trademark song was the risible “Shy,” a misapplied adjective to both Winnifred and Burnett. (It was reprised Monday night by D.C. actress Awa Sal Secka.)

Burnett told me a story about just how not shy she was. Back in the mid-1950s, after she landed in New York, fresh from UCLA with the name of one Broadway actor with a tangential personal connection, Eddie Foy Jr., she showed up at the stage door of the St. James Theatre, where Foy was appearing in “The Pajama Game.” She talked her way in and after Foy finished the curtain call, met him and explained she would like to get an agent.

Foy politely indulged her, she recalled. “He said: ‘What do you? Do you sing?’ I said, ‘Yeah, I’m loud.’ He said, ‘Do you read music?’ I said, ‘No.’ He said, ‘Do you dance?’ ‘I can jitterbug.’ He said, ‘Maybe I could get you the chorus.’ I said: ‘I’m really not good enough to do that. I think I’d have to have a featured role.’ ”

Her first encounter with Sondheim was in 1960. Burnett was rehearsing for a Thanksgiving TV special with Dick Van Dyke – she sang a number as a character who would become her trademark, the charwoman. “And this young man came up to me and introduced himself and said, ‘I’m Stephen Sondheim, and I really liked what you were doing.’ I had no idea who he was.” Only later would she realize that he wrote the musical whose run-through she and other Broadway actors had been invited to the previous year. That show was “Gypsy,” and he was its lyricist.

Their paths would converge to mutual benefit on her variety show, which she often used to feature his work. She sang “Broadway Baby” from “Follies” on one occasion; on another, she performed an 11-minute mini-musical built around “Side by Side by Side” from “Company” with Peters and Tony Roberts. Burnett ended that elaborate production number, set in a diner, with a spotlight on a large, autographed photo of Sondheim.

“It wasn’t like, ‘I’m gonna do this so you’ll know who Stephen Sondheim was,'” she explained. “I just did it because I love what he did.”

Over the years, their friendship deepened. Courtesy of that 1985 delivery of “I’m Still Here,” Burnett sealed a reputation as a leading Sondheim interpreter, a status reaffirmed by her casting, at the composer’s request, in the 1999 Sondheim revue “Putting It Together.” Staged by Signature’s former artistic director Eric Schaeffer, it ran on Broadway for 101 performances. Then again in 2005, she got the plum (and challenging) assignment of singing the eternally tongue-twisting “Getting Married Today” from “Company” at the star-studded 75th-birthday celebration for Sondheim at the Hollywood Bowl.

“It was hard, but I had time to learn it,” Burnett said of the song. “So that once you get it right, it’s in there. I even do it sometimes when I can’t go to sleep.”

You can tell that committing Sondheim’s lyrics to memory has been for Burnett a facet of a more profound commitment – just as he was committed to her. He spelled that out in a 2019 letter he had written to Signature in support of Burnett’s entry into the pantheon of Sondheim Award recipients, a letter read Monday night:

“We all know, Carol Burnett is a multitude of talents. To begin with, she can sing, and I mean sing! Her singing in fact is the most underrated gift she has. Then she can act, and not only that, sing and act at the same time, which is not as easy as it sounds. Especially if you also happen to be one of the funniest women alive. And then, of course, there’s her graciousness, which is one of the reasons that people love her as much as they do.”

Lately, Burnett’s public life has shifted from performance to reminiscence: Several times a year, she tours with a show that includes the question-and-answer format that memorably began each episode of “The Carol Burnett Show.” Remarkably, she said, YouTube and reruns on cable have kept her old TV show alive.

“A couple of years before the pandemic, there was a little boy in the second row who raised his hand that I called on,” Burnett recounted. “I said, ‘What’s your name?’ He said, ‘Andrew.’ And I said, ‘How old are you, Andrew?’ He said, ‘Nine.’ And I said, ‘You know who I am?’ And there was a pause, and he said, ‘Surprisingly, yes.’ ”

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Filed Under: Uncategorized Carol Burnett, Stephen Sondheim, Bernadette Peters, Beverly Sills, Randy Rainbow, Mary Rodgers, George Hearn, Harold Prince, Lee Remick, Andrew, Gwen Rainbow, ..., carol burnett show where are they now, carol burnett cast where are they now, carol burnett how much is she worth, how much carol burnett worth, best carol burnett bloopers, bloopers carol burnett, carol burnett remembers how they stopped the show, tim conway on carol burnett, tim conway on carol burnett show, carol burnett tv shows

GOP directs culture war fury toward green investing trend

May 19, 2022 by www.chron.com Leave a Comment

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SALT LAKE CITY (AP) — Republicans are coming out swinging against Wall Street’s growing efforts to consider factors like long-term environmental risk in investment decisions, the latest indication that the GOP is willing to damage its relationship with big business to score culture war points.

Many are targeting a concept known as ESG — which stands for environmental, social and governance — a sustainable investment trend sweeping the financial world. Red state officials deride it as politically correct and woke and are trying to stop investors who contract with states from adopting it on any level.

For right-wing activists who previously brought criticisms of critical race theory (CRT), diversity, equity and inclusion (DEI) and social emotional learning (SEL) to the forefront, it’s the latest acronym-based source of outrage to find a home at rallies, in conservative media and in legislatures.

ESG has yet to take hold as mainstream political messaging, but backlash against it is gaining steam. Last week, former Vice President Mike Pence attacked the concept during a speech in Houston. And on Wednesday, the same day he said on Twitter he planned to vote Republican, Elon Musk attacked it after Tesla lost its place on the S&P 500′s ESG Index. He called it a scam “weaponized by phony social justice warriors.”

The concept calls on investors to consider criteria such as environmental risk, pay equity or how transparent companies are in their accounting practices. Aided by recently proposed disclosure requirements and analysis from ratings agencies, they have adopted the principles to such an extent that those who use them control $16.6 trillion in investments held in the U.S.

In response, Republicans — historically known for supporting fewer regulations — are in many places attempting to impose new rules on investors. Their efforts reflect how members of the party are willing to distance themselves from big business to push back against those they see as ideological foes.

“I don’t think we’re the party of big business anymore. We’re the party of people — more specifically, we’re the party of working people. And the problem that we have is with big banks and corporations right now trying to dictate how we’re going to live our lives,” West Virginia Treasurer Riley Moore said.

Opponents criticize ESG as politicized and a potentially costly diversion from purely financial investment principles, while advocates say considering the criteria more accurately accounts for risk and promises steadier returns.

“We focus on sustainability not because we’re environmentalists, but because we are capitalists and fiduciaries to our clients,” Larry Fink, CEO of investment firm BlackRock and a leading proponent, told clients in a letter this year.

But Moore and others including Utah’s Republican state treasurer Marlo Oaks argue favoring green investment over fossil fuels denies key industries access to the financial system and capital. They have targeted S&P Global Ratings for appending ESG scores to their traditional state credit ratings. They worry that without changes, their scores could make borrowing for projects like schools or roads costlier.

In an April letter, Oaks demanded S&P retract analysis that rated Utah as “moderately negative” in terms of environmental risk due to “long-term challenges regarding water supply, which could remain a constraint for its economy … given pervasive drought conditions in the western U.S.”

The letter was co-signed by the governor, legislative leaders and the state’s congressional delegation, including Sen. Mitt Romney, whose former firm Bain Capital calls ESG factors “strategic, fact-based and diligence-driven.” It said ratings system “attempts to legitimize a dubious and unproven exercise” and attacks the “unreliability and inherently political nature of ESG factors in investment decisions.”

Though he likened ESG to critical race theory, Oaks said he was mostly concerned with capital markets and what he called attempts by fossil fuel opponents to manipulate them by pressuring investors to pick businesses with high ESG scores.

“DEI, CRT, SEL. It can be hard to keep up with the acronyms,” he wrote on an economics blog last month, “but there’s a relatively new one you need to know: ESG.”

Investors making carbon neutral or net zero criteria common were, in effect, Oaks said, limiting access to capital for oil and gas businesses, hurting their returns and potentially contributing to gas price spikes.

In more than a dozen red states, officials dispute the idea that the energy transition underway could make fossil fuel-related investments riskier in the long term. They argue employing asset managers with a preference for green investments uses state funds to further agendas out of sync with constituents.

In statehouses, anti-green investing efforts are backed by conservative groups such as the American Legislative Exchange Council and the Heartland Institute, a think-tank skeptical of scientific consensus on human-caused climate change that has backed bills that either divest state funds from financial institutions that use ESG or forbid them from using it to score businesses or individuals.

In Texas, West Virginia and Kentucky, lawmakers have passed bills requiring state funds limit transactions with companies that shun fossil fuels. Wyoming considered banning “social credit scores” that evaluate businesses using criteria that differ from accounting and other financial metrics, like ESG

After conservative talk show host Glenn Beck visited the Idaho Statehouse and referred to ESG as critical race theory “on steroids,” the Legislature passed a law in March prohibiting investment of state funds in companies that prioritize commitments to ESG over returns.

The American Legislative Exchange Council recently published model policy that would subject banks managing state pensions to new regulations limiting investments driven by what it calls “social, political and ideological” goals.

Though the policy doesn’t mention it outright, Jonathan Williams, the group’s chief economist, said ESG’s mainstreaming amid broader trends of political correctness was a driving force. He said his research shows that incorporating factors beyond traditional financial metrics can lower the rate of return for already underfunded state pensions.

Sustainable investing advocates deny that charge and say considering the risks and realities of climate change amounts to responsible investing.

West Virginia and Arkansas recently divested their pension funds from BlackRock in response to the asset manager adding businesses with smaller carbon footprints to its portfolios. Moore, West Virginia’s treasurer, hopes more will follow.

Though it’s drawing enthusiasm, the green investment discourse differs from recurring debates over gender and sexuality or how history is taught. Both proponents and detractors acknowledged they’re surprised pensions, credit ratings and investment decisions have become campaign rally fodder.

Last month at the Utah state party’s convention, thousands of Republicans roared when Sen. Mike Lee described green investment in similar terms to critical race theory — another acronym-based foil: “Between CRT and ESG and MSNBC, we get way too much B.S.,” Lee said.

Bryan McGannon, a lobbyist with US SIF: The Forum for Sustainable and Responsible Investment, said opponents were wrong in framing sustainable investing trends as political. If states refuse to reckon with how the future will likely rely less on fossil fuels and limit how environmental risk can be considered, he said, they’re making decisions with incomplete information.

“If a state’s not considering those risks, it may be a signal to an investor that this might not be a wise government to be putting our money with,” McGannon said. “Investors use a huge swath of information, and ESG is a piece of that mosaic.”

___

Associated Press writers Stan Choe in New York and Lindsay Whitehurst in Salt Lake City contributed to this report.

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New study finds direct link between diet and molecule linked to cancer – what to avoid

May 18, 2022 by www.express.co.uk Leave a Comment

Cancer symptoms: Top 14 early signs to look out for

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There are many factors that can influence cancer outcomes and isolating one at the expense of others results in misleading conclusions. Researchers exploring the role diet plays in the development of cancer routinely have to walk this tightrope. This careful approach was applied in a new study published in the ACS Central Science .

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The study implicates a high-fat diet in the development of cancer.

Researchers at the Beckman Institute for Advanced Science and Technology proved that a direct link exists between the amount of fat included in one’s diet and bodily levels of nitric oxide, a naturally occurring signalling molecule that is related to inflammation and cancer development.

“We are trying to understand how subtle changes in the tumour microenvironment affect cancer progression at the molecular level. Cancer is a very complicated disease,” said Anuj Yadav, a senior research associate and the study’s lead coauthor.

Mr Yadav explained that cancer isn’t just about a few tumour cells, but rather the entire microenvironment — or ecosystem — of the tumour supporting the cells.

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Study links high-fat diet to the development of cancer

Cancer warning: Study links high-fat diet to the development of cancer (Image: Getty Images)

“Inflammation can play a significant role in this environment. Certain inflammatory responses come from highly processed foods, which are high in calories and high in fat. We wanted to understand the links between food, inflammation, and tumours at a molecular level, so we had to develop advanced probes to be able to visualise these changes,” he said.

Mr Yadav and coauthors are familiar with existing research linking increased nitric oxide levels to inflammation, and inflammation to cancer.

Proving the connection between high-fat diets and nitric oxide levels on a molecular level required developing a highly sensitive molecular probe capable of deep-tissue imaging.

A molecular probe is a group of atoms or molecules used to study the properties of adjacent molecules by gauging the interactions between the probe and the structures of interest.

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But they are not one-size-fits-all. Each probe must be tailored to the conditions of its experiment.

“Our group specialises in making designer molecules, which allows us to look at molecular features that are invisible to the naked eye,” said Jefferson Chan, an associate professor of chemistry at the University of Illinois Urbana-Champaign and the study’s principal investigator.

“We design these custom-made molecules to discover things that weren’t previously known.”

The success of the study, which appeared in ACS Central Science in March, largely depended on the molecular probe designed by the team.

With this association now known, new implications exist for cancer treatment

Implications: With this association now known, new implications exist for cancer treatment (Image: Getty Images)

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Labeled BL660-NO, this probe is the first of its kind to be used in bioluminescence imaging of nitric oxide in cancer.

The researchers used the probe to design a diet study in mice, comparing the tumorigenicity of the breast-cancer-carrying mice on a high-fat diet (60 percent of calories coming from fat) with mice on a low-fat diet (10 percent of calories coming from fat) by measuring the nitric oxide levels in both groups.

“As a result of the high-fat diet, we saw an increase in nitric oxide in the tumour microenvironment,” said Michael Lee, a student researcher in the Chan lab and a lead coauthor on this study.

“The implication of this is that the tumour microenvironment is a very complex system, and we really need to understand it to understand how cancer progression works. A lot of factors can go into this from diet to exercise — external factors that we don’t really take into account that we should when we consider cancer treatments.”

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General signs and symptoms of cancer

Cancer: General signs and symptoms of cancer (Image: Getty Images)

The authors emphasised the importance of proving a direct link between a high-fat diet, nitric oxide levels, and cancer development.

With this association now known, new implications exist for cancer diagnosis and treatment.

“Without this technology, you wouldn’t see this missing molecular link,” said Professor Chan, who is also a faculty researcher at the Beckman Institute. “Now that we know that this is happening, how do we prevent it, and how do we improve the situation?”

A high-fat diet typically consists of at least 35 percent of total calories consumed from fats, both unsaturated and saturated.

In addition to the popular processed foods, many other foods have a high fat content including but not limited to animal fat, chocolate, butter.

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