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Britons to receive Covid vaccine targeting Omicron strain – the side effects to expect

by www.express.co.uk Leave a Comment

Omicron: GP explains ‘overwhelming’ science behind vaccines

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In a major win for Britain, the UK medicines regulator (MHRA) has approved the so-called bivalent vaccine made by US drug company Moderna as a jab for adults. It’s the first country to give the Covid booster jab the green light. The vaccine, which targets both the original and Omicron strain, was found to meet MHRA’s exacting standards of safety, quality and effectiveness. Reassuringly, the health body says that the vaccine’s side effects are the same as those seen in the original Moderna booster dose and were typically mild.

The agency’s decision was based on clinical trial data that showed the booster triggered “a strong immune response” against both Omicron (BA.1) and the original 2020 virus, it said.

The MHRA also cited an exploratory analysis in which the shot was also found to generate a good immune response against the currently dominant Omicron offshoots BA.4 and BA.5.

“The first generation of COVID-19 vaccines being used in the UK continue to provide important protection against the disease and save lives,” MHRA Chief Executive June Raine said in a statement.

“What this bivalent vaccine gives us is a sharpened tool in our armoury to help protect us against this disease as the virus continues to evolve.”

READ MORE: Long Covid causing ‘wider set’ of symptoms than previously thought – expert offers advice

UK approves new Covid vaccine targeting Omicron strain

Omicron jab: UK approves new Covid vaccine targeting Omicron strain (Image: Getty Images)

The Government’s independent science advisory body the Commission on Human Medicines also approved the jab.

Professor Sir Munir Pirmohamed, Chair of the Commission on Human Medicines said: “The Commission on Human Medicines and its COVID-19 Vaccines Expert Working Group has independently reviewed the data on safety, quality and effectiveness and agrees with the MHRA’s decision.”

The booster dose, also known as “Spikevax bivalent Original/Omicron”, contains 25 micrograms of Omicron vaccine and 25 micrograms of original coronavirus vaccine.

A vaccine that works for two infections is known as bivalent.

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The Joint Committee on Vaccination and Immunisation will advise on how the vaccine should be rolled out.

The dose is an updated version of the Moderna vaccine which is already in use for first, second and booster doses, and it will be the first dose approved in the UK which targets two strains of the virus.

Moderna’s chief medical officer, Doctor Paul Burton, previously said that the new jab can boost a person’s antibodies to such high levels that it may only be needed annually.

Stephane Bancel, chief executive officer at Moderna, described it as a “next generation COVID-19 vaccine” which will play an “important role in protecting people in the UK from COVID-19” over the winter.

READ MORE: Caught Covid? You could be at a threefold greater risk of permanent decline – new study

The jab is an updated version of the Moderna vaccine which is already in use

Bivalent vaccine: The jab is an updated version of the Moderna vaccine which is already in use (Image: Getty Images)

Mr Bancel said: “We are delighted with the MHRA’s authorisation of Spikevax Bivalent Original/Omicron, our next generation COVID-19 vaccine.

“This represents the first authorisation of an Omicron-containing bivalent vaccine, further highlighting the dedication and leadership of the UK public health authorities in helping to end the COVID-19 pandemic.

“This bivalent vaccine has an important role to play in protecting people in the UK from COVID-19 as we enter the winter months.”

Mr Bancel added that the jab has “consistently shown superior breadth of immune response” over alternatives in clinical trials.

The major development comes on the heels of a recent publication of a paper on COVID-19 vaccines in the Lancet journal .

The research paper suggested that COVID-19 vaccines have prevented up to 20 million deaths in the first year of use.

The researchers of the paper concluded: “COVID-19 vaccination has substantially altered the course of the pandemic, saving tens of millions of lives globally.”

Over 7 crore Covid vaccine lying with states

by health.economictimes.indiatimes.com Leave a Comment

NEW DELHI : More than seven crore doses of Covid-19 vaccine are lying unused with states and Union territories, the government said on Monday. According to an update from health ministry on vaccine availability, the government has provided more than 199.01 crore doses to states/UTs free of cost directly (via the free of cost channel) and through the direct state procurement system. “More than 7.06 crore balance and unutilised doses are still available with them,” it said.

India started its Covid vaccination drive on January 21, 2021. Till date, the health ministry said, 208.25 crore vaccine doses have been administered. “As part of the nationwide vaccination drive, the government of India has been supporting the states and UTs by providing them Covid vaccines free of cost. In the new phase of the universalisation of the Covid-19 vaccination drive, the Union government will procure and supply (free of cost) 75% of the vaccines being produced by the vaccine manufacturers in the country to states and UTs,” the health ministry said.

Several states, including Delhi and Maharashtra , have been witnessing a surge in Covid-19 cases over the past few weeks. The government has directed them to ensure adequate testing, promote Covid-appropriate behaviour and increase the pace of vaccination to contain the surge.

The symptoms and clinical manifestations of Covid-19 have undergone some changes. Therefore, the Centre has asked the states reporting a spike in cases to monitor and report district-wise ifluenza-lke-ilness (ILI) and SARI (severe acute respiratory infections) in all health facilities on a regular basis for detecting early warning signals of the spread of infection. “This will enable us to take pre-emptive action, if required, in any areas of concern,” the ministry said in an advisory sent to all states 10 days ago.

Though cases are rising, the need for hospitalisation remains low, a senior official said. However, he added that people as well as the policymakers must realise that if the infection keeps spreading it will reach the high-risk population and that may eventually lead to more severe symptoms also and, therefore, it was important to take all precautions to prevent disease spread and focus on vaccinating everyone.

Bharat Biotech seeks nod for intranasal Covid vaccine

by health.economictimes.indiatimes.com Leave a Comment

Bharat Biotech on Monday said that it has submitted data for approval of its intranasal vaccine to the drug regulator. The intranasal vaccine been tested as both a preliminary dose and a mix-and-match booster on licensed Covid vaccines, it said.

The company said that intra nasal vaccine has proven to be safe, well-tolerated, and immunogenic in subjects in controlled clinical trials. According to the vaccine maker, it conducted two separate and simultaneous clinical trials to evaluate its intranasal vaccine (BBV154) as a primary dose (2-dose) schedule, and a heterologous booster dose for subjects who have previously received 2 doses of the two commonly administered covid vaccines in India including Covishield and Covaxin .

The company said that data from both Phase III human clinical trials have been submitted for approval to drug regulatory authorities.

While the primary dose schedule phase III trials were conducted for safety, and immunogenicity in 3100 subjects, and compared with Covaxin. Its trials were conducted in 14 trial sites across India. For the heterologous booster dose, studies were conducted for safety and immunogenicity in 875 subjects, where a booster dose (3rd dose) of BBV154 intranasal vaccine was administered to study participants who were previously vaccinated with licensed Covid vaccines,” the company said. Adding that trials were conducted in 9 trial sites across India.

Bharat Biotech said that the intranasal vaccine may produce local antibodies in the upper respiratory tract which may provide the potential to reduce infection and transmission. The company plans to do further studies. “The nasal delivery system has been designed and developed to be cost-effective in low and middle-income countries,” it said.

The company said the intranasal vaccine has the double benefit of enabling faster development of variant-specific vaccines and easy nasal delivery that helps mass immunization protect from emerging concern variants.

Monkeypox Spread Continues In Riverside County

by patch.com Leave a Comment

Health & Fitness

A public health emergency proclamation was signed last week in Riverside County in an effort to focus attention on the local outbreak.

RIVERSIDE COUNTY, CA — Riverside County reported nine more confirmed or probable monkeypox cases Monday, raising the overall number to 87.

Jose Arballo, a spokesman for Riverside University Health System, said all the new cases were men, with three in Western Riverside County and six from the Coachella Valley.

Last Monday, Arballo reported the total probable/confirmed cases stood at 59.

Riverside County Public Health Officer Geoffrey Leung signed a public health emergency proclamation last week in an effort to focus attention on the virus, according to a statement from Riverside University Public Health.

“We have seen the devastating physical effects of monkeypox on those who have been infected, as well as the emotional toll on partners, family and loved ones,” Leung said in a statement. “Now is the time for Public Health, our community partners and local leadership to reinforce our commitment to work together to slow and eventually stop the spread of this virus.”

State and federal officials also proclaimed emergencies in response to monkeypox.

Riverside County health officials have distributed 75% of an allotment of monkeypox vaccine doses to DAP Health, Eisenhower Medical Center, Borrego Health and RUHS’ EIP clinic in the Coachella Valley from the county’s limited supply, Arballo told City News Service.

He said the county received 3,514 vaccine doses of the two-dose- regimen JYNNEOS monkeypox vaccine, enough for about 1,750 people, before the 75% were distributed into the Coachella Valley.

The other 25% were kept for RUHS Public Health efforts such as larger scale events and post-exposure prophylaxis, Arballo said.

“We continue to work on adding additional community partners to make our limited vaccine supply available more widely, as we also continue to advocate for more vaccine doses for our county,” Arballo said.

According to health officials, the vaccine can prevent infection if given before or shortly after exposure to the virus.

“By sharing the vaccine, which is in limited supply, we wanted to make it as easy as possible for patients to get the shot if they and their medical provider agree it is appropriate,” said Kim Saruwatari, director of public health for the county.

The county is also working with community partners to expand the eligibility for the two-shot vaccines to include at-risk individuals, and to set up treatment sites with Tecovirimat — an antiviral medication used to treat orthopoxvirus infections such as monkeypox.

The U.S. Centers for Disease Control and Prevention and the California Department of Public Health advise that the vaccine be prioritized for high- risk and exposed patients. Gay and bisexual men are at increased risk of contracting the virus, according to the CDC.

The World Health Organization has declared monkeypox a “public health emergency of international concern.”

As of Friday, a total of 1,945 monkeypox cases were confirmed in California — the second-highest of any state, behind New York’s 2,295 — while nationwide, the aggregate count was at 11,177, according to the latest CDC data.

Monkeypox is generally spread through intimate skin-to-skin contact, resulting from infectious rashes and scabs, though respiratory secretions and bodily fluids exchanged during extended physical episodes such as sexual intercourse can also lead to transmission, according to the CDC.

Symptoms include fresh pimples, blisters, rashes, fever and fatigue. There is no specific treatment. People who have been infected with smallpox, or have been vaccinated for it, may have immunity to monkeypox.

People with symptoms are urged to visit a medical provider, cover the rash area with clothing, wear a mask and avoid close or skin-to-skin contact with others.

The CDC particularly recommends those steps for people who recently traveled to an area where monkeypox cases have been reported or who have had contact with a confirmed or suspected monkeypox case.

A full list of countries that have confirmed monkeypox cases is available at wwwnc.cdc.gov/travel/notices/alert/monkeypox . A state-by-state tally of cases is available at www.cdc.gov/poxvirus/monkeypox/response/2022/us-map.html .

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Riverside County Holiday Events 2021: Christmas Parades & Santa

by patch.com Leave a Comment

Community Corner

Your guide to tree lightings, Hanukkah menorah fests, concerts, ice rinks, craft boutiques, light shows, Nutcrackers & festivities.

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INLAND EMPIRE, CA — Get out your calendars! Time to start planning as the holidays near throughout Riverside County and the Inland Empire.

Christmas this year falls on a Saturday, Dec. 25. Hanukkah 2021 comes a bit early, beginning Sunday, Nov. 28 at sundown and running through Monday, Dec. 6.

Peruse Patch’s annual holiday guide, find nearby events and select outings that appeal to you and yours. Many events kick off soon, while several require advance bookings, and space may be limited.

Note: Always confirm with organizers that the listed activities are proceeding as planned when posted.

And to all of our readers, wishing you the happiest of holidays, from Patch!

BEAUMONT:

DEC. 1: Annual Christmas Tree Festival: St. Stephen’s Church . With tea luncheons Dec. 3 & 4.

DEC. 11: Holiday Light Parade: Downtown . A community show of holiday spirit!

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CATHEDRAL CITY:

DEC. 8: North Pole Village & Tree Lighting . With music, carolers & free holiday movie.

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CHERRY VALLEY:

NOV. 3 – JAN. 9, 2022: Christmas Nights: 123 Farm & Highland Springs Ranch . Offering wagon adventure, food, drinks & Santa!

DEC. 3-4: Winterfest – Snow, Sledding & Santa . Parking and admission are free.

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CRESTLINE:

DEC. 11: A Very Bizzy Christmas & Santa: Bizzyland Gardens . With carolers, too!

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DESERT HOT SPRINGS:

DEC. 11: Parade Of Lights, Holiday Festival & Santa . Fun includes free carnival rides & photos with Santa.

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HEMET:

DEC. 4: ‘Caroling Nights & Magical Lights’ Christmas Parade . With events at Weston Park.

DEC. 12: Tinsel Triathlon & 5K . “The largest & longest running Reverse Sprint Pool Triathlon on the West Coast.”

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INDIO:

DEC. 4-5: Annual Tamale Festival: Entertainment & Carnival Rides . “A rich multi-cultural & multi-generational experience complemented by holiday shopping.”

DEC. 11: Holiday Craft Fair . Space is limited. With family craft stations, too.

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JOSHUA TREE:

DEC. 18: Full Moon Winter Solstice Event ~ Breathwork SoundLab . “A powerful fusion of rhythmic breathwork and a sound bath.”

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LA QUINTA:

DEC. 3: Tree-Lighting Ceremony . Annual event at Civic Center Park.

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LAKE ELSINORE:

DEC. 4: Winterfest: Holiday Parade, Tree Lighting, Sledding & Santa . Parade kicks off at 3 p.m.!

DEC. 8-19: Winter Lights Kingdom . A Christmas drive-thru event at Storm.

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LOMA LINDA:

DEC. 12: Holiday Classic Half Marathon, 5K & Elves Tro t . “Elves Trot fun run for children ages 3-6. Every participating elf will receive an adorable Santa medal.”

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MENIFEE:

NOV. 30: Hanukkah Menorah Lighting: Central Park . Join in lighting of giant menorah.

DEC. 4: Christmas Tree Lighting, Parade, Snow & Santa . Canned goods or toy donations accepted for snow-area admission.

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MURRIETA:

DEC. 4: Donuts With Santa . Three locations. First-come, first-served.

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NORCO:

NOV. 11: SilverLakes Christmas Market . Live entertainment & artisans galore.

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PALM DESERT:

NOV. 23-DEC. 30: Holiday ‘WildLights’: Living Desert Zoo & Gardens . Advance reservations needed, so book soon.

NOV. 27-DEC. 18: Holiday ‘Merry Movie Nights’: Gardens On El Paseo . Family-friendly fun! Don’t forget blankets.

DEC. 3: Annual Tree-Lighting Ceremony & Santa: Shops On El Paseo . Event also kicks off toy drive.

DEC. 11: Breakfast With Santa . With craft stations for ornament & cookie decorating.

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PALM SPRINGS:

DEC. 3-4: ‘The Skivvies – Say It Ain’t Snow!’: Purple Room Supper Club . “Perfect combination of naughty and nice with undie-rock at its finest.”

DEC. 4: Festival Of Lights Parade . “Voted one of the Top Ten Holiday Parades in the country.”

DEC. 9-26: Desert Rose Playhouse ‘Christmas With The Crawfords’ – “A 90-minute parade of famous movie stars dropping by unannounced to sing, dance & generally toss each other around.”

DEC. 18-22: Santa Fly-In & Winter Light Show: Air Museum . “Santa Claus will arrive at the Air Museum in his helicopter to greet all the good little girls and boys who have come to see him.”

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PERRIS:

NOV. 24-DEC. 31: ‘The Polar Express’ & Santa: Southern California Railway Museum . “Relive the magic of the classic story.”

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REDLANDS:

NOV. 19: Downtown Holiday Lighting Ceremony & Santa . With carolers, music, free hot cocoa, bounce house & more.

DEC. 4: Annual Downtown Christmas Parade . 2021 theme: “An Unforgettable Christmas.”

DEC. 4: Stuff A Plane For Charity . Toy drive to benefit The Salvation Army San Bernardino Corps.

DEC. 4-5: Holiday Boutique Weekend . Proceeds benefit the YMCA of the East Valley Legal Aid Clinic.

DEC. 5: Holiday Home Tour . Tickets are on sale.

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RIVERSIDE:

NOV. 26-JAN. 6: Mission Inn Hotel’s ‘Festival Of Lights ‘ – No “Switch-On Ceremony” this year, but the holiday display will go on for the season.

DEC. 11-12 & 18-19: The Nutcracker . At Fox Performing Arts Center with critically acclaimed Inland Pacific Ballet.

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SAN BERNARDINO:

DEC. 3-5: Inland Dance Theatre ‘Nutcracker’: California Theatre . A local family tradition!

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TEMECULA:

NOV. 15-DEC. 31: Peltzer Holiday Ice Skating Rink . Fun includes picnic benches, hot cocoa, snacks, food truck eats & bar serving Peltzer Wine.

NOV. 20: Holiday Hugs Market & Toy Drive . With kids’ activities, crafts, Santa & more.

NOV. 26-28: ‘The Nutcracker Ballet’ – “This extravagant production is ideal for children.”

NOV. 28: Tree Lighting Fest, Carriage Rides & Santa: South Coast Winery . Tickets required & on sale.

NOV. 28: Duck Pond Menorah Lighting – Hanukkah . “Light the giant menorah at the duck pond.”

NOV. 29: Christmas Tree Lighting & Santa: Duck Pond . With treats, festive music & visit from Santa.

DEC. 3: Santa’s Electric Light Parade . Bring blankets, chairs & line up for fun holiday extravaganza.

DEC. 4-12: ‘A Christmas Carol – The Musical ‘ – “An Old Town Temecula family favorite!”

DEC. 5: Chanukah Car Menorah Parade . Through Old Town & the Mall.

DEC. 9-JAN. 2: ‘Temecula On Ice’ Skating Rink 2021: Town Square Park . With “its own radio station playing the best ice skating music.”

DEC. 12: ‘Candlelight Classics’ Holiday Concert: The Merc . Seating limited, so book soon.

DEC. 17-23: ‘The Nutcracker Ballet’ – “One of the best to see in Southern California.”

DEC. 18: ‘Chilled In The Park’ Fest & Holiday Fireworks . Also featuring entertainment, ugly sweater contest & kids’ zone.

DEC. 31: BAD CHEMISTRY @ OTBC New Years Eve 2021 . At Old Town Blues Club.

DEC. 31-JAN. 1: New Year’s Eve Grape Drop . With music, food trucks & kids’ zone.

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UPLAND:

DEC. 4: Christmas Parade & Holiday Fair e . The Holiday Faire tradition features food and gift vendors and more!

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